Messi scored his 4 the team first from the penalty spot, with his second a curler from the edge of the box in the 64th minute.
Kevin Gameiro struck the opener for the visitors, after which Daniel Parejo doubled their lead from the penalty spot.
He suffered a knock to his right thigh soon afterwards, and there was an injury scare but is expected to be fit for Wednesday’s Copa del Rey semi-final first leg against Real Madrid.
Space was at a premium in the Valencia area as they tried to hold out for the win but Messi found enough to turn and curl a stunning effort past a helpless Neto to earn a point for the Spanish champions. Messi has proved his uniqueness several times on the Nou camp, and he keeps showing his relevance and worh to the team